Marie Curie FP7 People EID PhD/ Early Stage Research Studentship

Modelling Cardiovascular Safety- Target Engagement Exposure

University of Warwick -School of Engineering

The aim of this project is to build a combined mathematical picture of cardiovascular parameters (QT, HR and BP) and their translation between in vitro, in vivo and clinical outcomes. The work will involve (1) quantification of exposure effect relationships for individual cardiovascular parameters in preclinical species and man for reference agents with different mechanisms-of-action, (2) development of translational system pharmacology framework to describe, explain and predict the cardiovascular (side) effects in preclinical and clinical species by separating drug- and system-specific parameters, (3) incorporation of the mechanism-of-action (in vitro observations on multichannel inhibition) into translational systems pharmacology models. The aim of this work is to define the optimal approach to accurately predict the risks for cardiovascular safety in clinical studies.

Awards available: 1 award available

Funding Details: The successful applicant will receive a stipend of £46,000 per annum over three years.

Length of Award: 3 years

Eligibility: 

Applicants eligible for this studentship must be UK/EU candidates only. This project is one of five forming the Innovative Modelling for Pharmacological Advances through Collaborative Training (IMPACT) project funded through the FP7 Marie Curie European Industrial Doctorate scheme. The Early Stage Researchers will spend 50% of their time based with the private sector partner AstraZeneca (Sweden), and a further 1/3 of their time at the University of Warwick, with the remaining periods of time on secondment based at the projects associate partner sites.

Application Details:   

Candidates should have a minimum first or upper second class honours degree (or equivalent) in a suitable branch of Engineering, or the equivalent in a suitable Science/Engineering degree. We ask that you submit the online application and upload your CV and transcripts.

You must complete the online application form quoting scholarship reference: MJC-04

http://www.go.warwick.ac.uk/pgapply.

Deadline: 22^nd February 2013

Start date: 1^st June 2013